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BMCBI
2005
106views more  BMCBI 2005»
13 years 5 months ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
BIOCOMP
2007
13 years 7 months ago
Biomarker Discovery Across Annotated and Unannotated Microarray Datasets Using Semi-Supervised Learning
The growing body of DNA microarray data has the potential to advance our understanding of the molecular basis of disease. However annotating microarray datasets with clinically us...
Cole Harris, Noushin Ghaffari
BMCBI
2004
114views more  BMCBI 2004»
13 years 5 months ago
Profiled support vector machines for antisense oligonucleotide efficacy prediction
Background: This paper presents the use of Support Vector Machines (SVMs) for prediction and analysis of antisense oligonucleotide (AO) efficacy. The collected database comprises ...
Gustavo Camps-Valls, Alistair M. Chalk, Antonio J....
BMCBI
2010
113views more  BMCBI 2010»
13 years 6 months ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
BMCBI
2006
118views more  BMCBI 2006»
13 years 6 months ago
Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis
Background: Concerns are often raised about the accuracy of microarray technologies and the degree of cross-platform agreement, but there are yet no methods which can unambiguousl...
Andrew J. Holloway, Alicia Oshlack, Dileepa S. Diy...