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BMCBI
2011
12 years 11 months ago
SNPPicker: High quality tag SNP selection across multiple populations
Background: Linkage Disequilibrium (LD) bin-tagging algorithms identify a reduced set of tag SNPs that can capture the genetic variation in a population without genotyping every s...
Hugues Sicotte, David N. Rider, Gregory A. Poland,...
BMCBI
2011
12 years 9 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu
BMCBI
2010
164views more  BMCBI 2010»
13 years 5 months ago
Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions
Background: The pan-genome of a bacterial species consists of a core and an accessory gene pool. The accessory genome is thought to be an important source of genetic variability i...
Chad Laing, Cody Buchanan, Eduardo N. Taboada, Yon...
BMCBI
2006
134views more  BMCBI 2006»
13 years 5 months ago
Application of machine learning in SNP discovery
Background: Single nucleotide polymorphisms (SNP) constitute more than 90% of the genetic variation, and hence can account for most trait differences among individuals in a given ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...
BMCBI
2008
88views more  BMCBI 2008»
13 years 5 months ago
Large-scale identification of polymorphic microsatellites using an in silico approach
Background: Simple Sequence Repeat (SSR) or microsatellite markers are valuable for genetic research. Experimental methods to develop SSR markers are laborious, time consuming and...
Jifeng Tang, Samantha J. Baldwin, Jeanne M. E. Jac...