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» Smoothing Gene Expression Using Biological Networks
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BMCBI
2010
133views more  BMCBI 2010»
13 years 5 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2010
165views more  BMCBI 2010»
13 years 5 months ago
MTar: a computational microRNA target prediction architecture for human transcriptome
Background: MicroRNAs (miRNAs) play an essential task in gene regulatory networks by inhibiting the expression of target mRNAs. As their mRNA targets are genes involved in importa...
Vinod Chandra, Reshmi Girijadevi, Achuthsankar S. ...
APBC
2004
122views Bioinformatics» more  APBC 2004»
13 years 6 months ago
Integrating Biopathway Databases for Large-scale Modeling and Simulation
Biopathway databases have been developed, such as KEGG and EcoCyc, that compile interaction structures of biopathways together with biological annotations. However, these biopathw...
Masao Nagasaki, Atsushi Doi, Hiroshi Matsuno, Sato...
BMCBI
2006
113views more  BMCBI 2006»
13 years 5 months ago
GibbsST: a Gibbs sampling method for motif discovery with enhanced resistance to local optima
Background: Computational discovery of transcription factor binding sites (TFBS) is a challenging but important problem of bioinformatics. In this study, improvement of a Gibbs sa...
Kazuhito Shida
SIAMSC
2008
149views more  SIAMSC 2008»
13 years 5 months ago
Adaptive Discrete Galerkin Methods Applied to the Chemical Master Equation
In systems biology, the stochastic description of biochemical reaction kinetics is increasingly being employed to model gene regulatory networks and signalling pathways. Mathematic...
Peter Deuflhard, Wilhelm Huisinga, T. Jahnke, Mich...