31 search results - page 1 / 7 » Somatic evolution of cancer |
RECOMB
2004
Springer
14 years 5 months ago
2004
Springer
We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, wh...
NAR
2011
12 years 7 months ago
2011
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding mutations in ...
BMCBI
2010
13 years 5 months ago
2010
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
ICASSP
2011
IEEE
12 years 8 months ago
2011
IEEE
In this paper we model and simulate a biological system describing the evolution of cancer stem cells into tumors. Starting from some basic hypotheses about the behavior of these ...
BMCBI
2008
13 years 5 months ago
2008
Background: DNA sequencing is now emerging as an important component in biomedical studies of diseases like cancer. Short-read, highly parallel sequencing instruments are expected...