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» Species-specific protein sequence and fold optimizations
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BMCBI
2007
216views more  BMCBI 2007»
13 years 6 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
BICOB
2010
Springer
13 years 4 months ago
Multiple Kernel Learning for Fold Recognition
Fold recognition is a key problem in computational biology that involves classifying protein sharing structural similarities into classes commonly known as "folds". Rece...
Huzefa Rangwala
GECCO
2005
Springer
119views Optimization» more  GECCO 2005»
13 years 11 months ago
A multi-objective evolutionary approach to peptide structure redesign and stabilization
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...
Tim Hohm, Daniel Hoffmann
BMCBI
2010
116views more  BMCBI 2010»
13 years 6 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
JCB
2006
215views more  JCB 2006»
13 years 6 months ago
Protein Fold Recognition Using Segmentation Conditional Random Fields (SCRFs)
Protein fold recognition is an important step towards understanding protein three-dimensional structures and their functions. A conditional graphical model, i.e., segmentation con...
Yan Liu 0002, Jaime G. Carbonell, Peter Weigele, V...