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JCB
2008
106views more  JCB 2008»
10 years 4 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin
BMCBI
2008
149views more  BMCBI 2008»
10 years 4 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal
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