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» TAPPA: topological analysis of pathway phenotype association
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BMCBI
2011
13 years 1 days ago
Pathway-based analysis using reduced gene subsets in genome-wide association studies
Background: Single Nucleotide Polymorphism (SNP) analysis only captures a small proportion of associated genetic variants in Genome-Wide Association Studies (GWAS) partly due to s...
Jingyuan Zhao, Simone Gupta, Mark Seielstad, Jianj...
BMCBI
2006
112views more  BMCBI 2006»
13 years 5 months ago
Phylophenetic properties of metabolic pathway topologies as revealed by global analysis
Background: As phenotypic features derived from heritable characters, the topologies of metabolic pathways contain both phylogenetic and phenetic components. In the post-genomic e...
Yong Zhang, Shaojuan Li, Geir Skogerbø, Zhi...
BMCBI
2008
129views more  BMCBI 2008»
13 years 5 months ago
Gene set enrichment analysis for non-monotone association and multiple experimental categories
Background: Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and expression...
Rongheng Lin, Shuangshuang Dai, Richard D. Irwin, ...
ISVC
2010
Springer
13 years 3 months ago
Visual Network Analysis of Dynamic Metabolic Pathways
We extend our previous work on the exploration of static metabolic networks to evolving, and therefore dynamic, pathways. We apply our visualization software to data from a simulat...
Markus Rohrschneider, Alexander Ullrich, Andreas K...