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» THEMATICS is Effective for Active Site Prediction in Compara...
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APBC
2004
166views Bioinformatics» more  APBC 2004»
13 years 6 months ago
THEMATICS is Effective for Active Site Prediction in Comparative Model Structures
THEMATICS (Theoretical Microscopic Titration Curves) is a simple, reliable computational predictor of the active sites of enzymes from structure. Our method, based on well-establi...
Ihsan A. Shehadi, Alper Uzun, Leonel F. Murga, Val...
BMCBI
2007
89views more  BMCBI 2007»
13 years 4 months ago
Selective prediction of interaction sites in protein structures with THEMATICS
Background: Methods are now available for the prediction of interaction sites in protein 3D structures. While many of these methods report high success rates for site prediction, ...
Ying Wei, Jaeju Ko, Leonel F. Murga, Mary Jo Ondre...
BMCBI
2008
130views more  BMCBI 2008»
13 years 5 months ago
Structural descriptor database: a new tool for sequence-based functional site prediction
Background: The Structural Descriptor Database (SDDB) is a web-based tool that predicts the function of proteins and functional site positions based on the structural properties o...
Juliana S. Bernardes, Jorge H. Fernandez, Ana Tere...
BMCBI
2007
139views more  BMCBI 2007»
13 years 5 months ago
Improving model predictions for RNA interference activities that use support vector machine regression by combining and filterin
Background: RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathwa...
Andrew S. Peek
GCB
2005
Springer
117views Biometrics» more  GCB 2005»
13 years 10 months ago
Generation of 3D templates of active sites of proteins with rigid prosthetic groups
Motivation: With the increasing availability of protein structures, the generation of biologically meaningful 3D patterns from the simultaneous alignment of several protein struct...
Jean-Christophe Nebel