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BMCBI
2006
86views more  BMCBI 2006»
13 years 4 months ago
The impact of sample imbalance on identifying differentially expressed genes
Background: Recently several statistical methods have been proposed to identify genes with differential expression between two conditions. However, very few studies consider the p...
Kun Yang, Jianzhong Li, Hong Gao
BIOINFORMATICS
2010
250views more  BIOINFORMATICS 2010»
13 years 3 months ago
DEGseq: an R package for identifying differentially expressed genes from RNA-seq data
Summary: High-throughput RNA sequencing (RNA-seq) is rapidly emerging as a major quantitative transcriptome profiling platform. Here we present DEGseq, an R package to identify di...
Likun Wang, Zhixing Feng, Xi Wang, Xiaowo Wang, Xu...
BMCBI
2011
12 years 11 months ago
The impact of quantitative optimization of hybridization conditions on gene expression analysis
Background: With the growing availability of entire genome sequences, an increasing number of scientists can exploit oligonucleotide microarrays for genome-scale expression studie...
Peter Sykacek, David P. Kreil, Lisa A. Meadows, Ri...
BMCBI
2004
113views more  BMCBI 2004»
13 years 4 months ago
Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide array
Background: To identify differentially expressed genes across experimental conditions in oligonucleotide microarray experiments, existing statistical methods commonly use a summar...
Leah Barrera, Chris Benner, Yong-Chuan Tao, Elizab...
RECOMB
2009
Springer
14 years 5 months ago
A Robust Bayesian Two-Sample Test for Detecting Intervals of Differential Gene Expression in Microarray Time Series
Abstract. Understanding the regulatory mechanisms that are responsible for an organism's response to environmental changes is an important question in molecular biology. A fir...
Oliver Stegle, Katherine J. Denby, David L. Wild, ...