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ISMB
1993
13 years 6 months ago
Using Dirichlet Mixture Priors to Derive Hidden Markov Models for Protein Families
A Bayesian method for estimating the amino acid distributions in the states of a hidden Markov model (HMM) for a protein familyor the columns of a multiple alignment of that famil...
Michael Brown, Richard Hughey, Anders Krogh, I. Sa...
BMCBI
2007
130views more  BMCBI 2007»
13 years 5 months ago
HMM-ModE - Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying e
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
Prashant K. Srivastava, Dhwani K. Desai, Soumyadee...
JCB
2000
107views more  JCB 2000»
13 years 4 months ago
A Discriminative Framework for Detecting Remote Protein Homologies
A new method for detecting remote protein homologies is introduced and shown to perform well in classifying protein domains by SCOP superfamily. The method is a variant of support...
Tommi Jaakkola, Mark Diekhans, David Haussler
BMCBI
2010
152views more  BMCBI 2010»
13 years 5 months ago
Apples and oranges: avoiding different priors in Bayesian DNA sequence analysis
Background: One of the challenges of bioinformatics remains the recognition of short signal sequences in genomic DNA such as donor or acceptor splice sites, splicing enhancers or ...
Jens Keilwagen, Jan Grau, Stefan Posch, Ivo Grosse
NIPS
2008
13 years 6 months ago
Logistic Normal Priors for Unsupervised Probabilistic Grammar Induction
We explore a new Bayesian model for probabilistic grammars, a family of distributions over discrete structures that includes hidden Markov models and probabilistic context-free gr...
Shay B. Cohen, Kevin Gimpel, Noah A. Smith