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BMCBI
2010
191views more  BMCBI 2010»
13 years 4 months ago
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...
BMCBI
2005
88views more  BMCBI 2005»
13 years 4 months ago
Using large-scale perturbations in gene network reconstruction
Background: Recent analysis of the yeast gene network shows that most genes have few inputs, indicating that enumerative gene reconstruction methods are both useful and computatio...
Thomas MacCarthy, Andrew Pomiankowski, Robert Seym...
BMCBI
2007
114views more  BMCBI 2007»
13 years 4 months ago
Large scale statistical inference of signaling pathways from RNAi and microarray data
Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
Holger Fröhlich, Mark Fellmann, Holger Sü...
CSB
2005
IEEE
180views Bioinformatics» more  CSB 2005»
13 years 10 months ago
Functional Modularity in a Large-Scale Mammalian Molecular Interaction Network
The Ingenuity™ Pathways Knowledge Base (IPKB) contains over one million findings manually curated from the scientific literature. Highly-structured content from the IPKB forms...
Andreas Kramer, Daniel R. Richards, James O. Bowlb...
BMCBI
2008
220views more  BMCBI 2008»
13 years 4 months ago
Gene prediction in metagenomic fragments: A large scale machine learning approach
Background: Metagenomics is an approach to the characterization of microbial genomes via the direct isolation of genomic sequences from the environment without prior cultivation. ...
Katharina J. Hoff, Maike Tech, Thomas Lingner, Rol...