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BMCBI
2010
147views more  BMCBI 2010»
13 years 5 months ago
baySeq: Empirical Bayesian methods for identifying differential expression in sequence count data
Background: High throughput sequencing has become an important technology for studying expression levels in many types of genomic, and particularly transcriptomic, data. One key w...
Thomas J. Hardcastle, Krystyna A. Kelly
BMCBI
2010
81views more  BMCBI 2010»
13 years 4 months ago
Empirical Bayes Analysis of Sequencing-based Transcriptional Profiling without Replicates
Background: Recent technological advancements have made high throughput sequencing an increasingly popular approach for transcriptome analysis. Advantages of sequencing-based tran...
Zhijin Wu, Bethany D. Jenkins, Tatiana A. Rynearso...
BMCBI
2006
153views more  BMCBI 2006»
13 years 5 months ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...
BMCBI
2010
136views more  BMCBI 2010»
13 years 5 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
BMCBI
2004
134views more  BMCBI 2004»
13 years 4 months ago
Bayesian model accounting for within-class biological variability in Serial Analysis of Gene Expression (SAGE)
Background: An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature ...
Ricardo Z. N. Vêncio, Helena Brentani, Diogo...