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JCB
2008
94views more  JCB 2008»
13 years 5 months ago
Prioritize and Select SNPs for Association Studies with Multi-Stage Designs
Large-scale whole genome association studies are increasingly common, due in large part to recent advances in genotyping technology. With this change in paradigm for genetic studi...
Jing Li
JCB
2008
106views more  JCB 2008»
13 years 5 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin
JCB
2008
90views more  JCB 2008»
13 years 5 months ago
A Simple Model of the Modular Structure of Transcriptional Regulation in Yeast
Resolving the general organizational principles that govern the interactions during transcriptional gene regulation has great relevance for understanding disease progression, biof...
Vladimir Filkov, Nameeta Shah
JCB
2008
52views more  JCB 2008»
13 years 5 months ago
Spectrum-Based De Novo Repeat Detection in Genomic Sequences
A novel approach to the detection of genomic repeats is presented in this paper. The technique, dubbed SAGRI (Spectrum Assisted Genomic Repeat Identifier), is based on the spectru...
Huy Hoang Do, Kwok Pui Choi, Franco P. Preparata, ...
JCB
2008
91views more  JCB 2008»
13 years 5 months ago
Computational Quantification of Peptides from LC-MS Data
Liquid chromatography coupled to mass spectrometry (LC-MS) has become a major tool for the study of biological processes. High-throughput LC-MS experiments are frequently conducte...
Ole Schulz-Trieglaff, Rene Hussong, Clemens Gr&oum...