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RECOMB
2008
Springer
14 years 5 months ago
Algorithms for Joint Optimization of Stability and Diversity in Planning Combinatorial Libraries of Chimeric Proteins
Abstract. In engineering protein variants by constructing and screening combinatorial libraries of chimeric proteins, two complementary and competing goals are desired: the new pro...
Wei Zheng, Alan M. Friedman, Chris Bailey-Kellogg
RECOMB
2008
Springer
14 years 5 months ago
Bootstrapping the Interactome: Unsupervised Identification of Protein Complexes in Yeast
Protein interactions and complexes are major components of biological systems. Recent genome-wide applications of tandem affinity purification (TAP) in yeast have increased signifi...
Caroline C. Friedel, Jan Krumsiek, Ralf Zimmer
RECOMB
2008
Springer
14 years 5 months ago
Accurate Computation of Likelihoods in the Coalescent with Recombination Via Parsimony
Understanding the variation of recombination rates across a given genome is crucial for disease gene mapping and for detecting signatures of selection, to name just a couple of app...
Jotun Hein, Rune B. Lyngsø, Yun S. Song
RECOMB
2008
Springer
14 years 5 months ago
Integrating Sequence and Topology for Efficient and Accurate Detection of Horizontal Gene Transfer
Abstract. One phylogeny-based approach to horizontal gene transfer (HGT) detection entails comparing the topology of a gene tree to that of the species tree, and using their differ...
Cuong Than, Guohua Jin, Luay Nakhleh