BMCBI
2008
13 years 5 months ago
2008
Background: Most microarray studies are made using labelling with one or two dyes which allows the hybridization of one or two samples on the same slide. In such experiments, the ...
BMCBI
2008
13 years 5 months ago
2008
Background: Machine-learning tools have gained considerable attention during the last few years for analyzing biological networks for protein function prediction. Kernel methods a...
BMCBI
2008
13 years 5 months ago
2008
Background: Optimization theory has been applied to complex biological systems to interrogate network properties and develop and refine metabolic engineering strategies. For examp...
BMCBI
2008
13 years 5 months ago
2008
Background: Large-scale, comprehensive and standardized high-throughput mouse phenotyping has been established as a tool of functional genome research by the German Mouse Clinic a...
BMCBI
2008
13 years 5 months ago
2008
Background: A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS) in drug di...
BMCBI
2008
13 years 5 months ago
2008
Background: Microarray-based pooled DNA experiments that combine the merits of DNA pooling and gene chip technology constitute a pivotal advance in biotechnology. This new techniq...
BMCBI
2008
13 years 5 months ago
2008
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
BMCBI
2008
13 years 5 months ago
2008
Background: The subcellular localisation of proteins in intact living cells is an important means for gaining information about protein functions. Even dynamic processes can be ca...
BMCBI
2008
13 years 5 months ago
2008
Background: In the last five years large online resources of human variability have appeared, notably HapMap, Perlegen and the CEPH foundation. These databases of genotypes with p...
BMCBI
2008
13 years 5 months ago
2008
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...