BMCBI
2010
13 years 5 months ago
2010
Background: Genome-wide association studies (GWAS) based on single nucleotide polymorphisms (SNPs) revolutionized our perception of the genetic regulation of complex traits and di...
BMCBI
2010
13 years 5 months ago
2010
Background: Sequencing metagenomes that were pre-amplified with primer-based methods requires the removal of the additional tag sequences from the datasets. The sequenced reads ca...
BMCBI
2010
13 years 5 months ago
2010
Background: This paper introduces the notion of optimizing different norms in the dual problem of support vector machines with multiple kernels. The selection of norms yields diff...
BMCBI
2010
13 years 5 months ago
2010
Background: Mitochondrial DNA (mtDNA) is widely being used for population genetics, forensic DNA fingerprinting and clinical disease association studies. The recent past has uncov...
BMCBI
2010
13 years 5 months ago
2010
Background: Finding the subgraphs of a graph database that are isomorphic to a given query graph has practical applications in several fields, from cheminformatics to image unders...
BMCBI
2010
13 years 5 months ago
2010
Background: Biological knowledge is represented in scientific literature that often describes the function of genes/ proteins (bioentities) in terms of their interactions (biointe...
BMCBI
2010
13 years 5 months ago
2010
Background: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on es...
BMCBI
2010
13 years 5 months ago
2010
Background: A large effort to discover microRNAs (miRNAs) has been under way. Currently miRBase is their primary repository, providing annotations of primary sequences, precursors...
BMCBI
2010
13 years 5 months ago
2010
Background: Selective pressure in molecular evolution leads to uneven distributions of amino acids and nucleotides. In fact one observes correlations among such constituents due t...
BMCBI
2010
13 years 5 months ago
2010
Background: Prognosis is of critical interest in breast cancer research. Biomedical studies suggest that genomic measurements may have independent predictive power for prognosis. ...