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JBI
2008
159views Bioinformatics» more  JBI 2008»
9 years 10 months ago
SEGS: Search for enriched gene sets in microarray data
Gene Ontology (GO) terms are often used to interpret the results of microarray experiments. The most common approach is to perform Fisher's exact tests to find gene sets anno...
Igor Trajkovski, Nada Lavrac, Jakub Tolar
BMCBI
2007
166views more  BMCBI 2007»
9 years 10 months ago
How to decide which are the most pertinent overly-represented features during gene set enrichment analysis
Background: The search for enriched features has become widely used to characterize a set of genes or proteins. A key aspect of this technique is its ability to identify correlati...
Roland Barriot, David J. Sherman, Isabelle Dutour
BMCBI
2006
147views more  BMCBI 2006»
9 years 10 months ago
Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data
Background: Gene Ontology (GO) terms are often used to assess the results of microarray experiments. The most common way to do this is to perform Fisher's exact tests to find...
Alex Lewin, Ian C. Grieve
BMCBI
2006
106views more  BMCBI 2006»
9 years 10 months ago
GONOME: measuring correlations between GO terms and genomic positions
Background:Current methods to find significantly under- and over-represented gene ontology (GO) terms in a set of genes consider the genes as equally probable "balls in a bag...
Stefan M. Stanley, Timothy L. Bailey, John S. Matt...
BMCBI
2008
146views more  BMCBI 2008»
9 years 10 months ago
ProLoc-GO: Utilizing informative Gene Ontology terms for sequence-based prediction of protein subcellular localization
Background: Gene Ontology (GO) annotation, which describes the function of genes and gene products across species, has recently been used to predict protein subcellular and subnuc...
Wen-Lin Huang, Chun-Wei Tung, Shih-Wen Ho, Shiow-F...
BMCBI
2008
170views more  BMCBI 2008»
9 years 10 months ago
Evaluation of GO-based functional similarity measures using S. cerevisiae protein interaction and expression profile data
Background: Researchers interested in analysing the expression patterns of functionally related genes usually hope to improve the accuracy of their results beyond the boundaries o...
Tao Xu, LinFang Du, Yan Zhou
BMCBI
2007
168views more  BMCBI 2007»
9 years 10 months ago
GOSim - an R-package for computation of information theoretic GO similarities between terms and gene products
Background: With the increased availability of high throughput data, such as DNA microarray data, researchers are capable of producing large amounts of biological data. During the...
Holger Fröhlich, Nora Speer, Annemarie Poustk...
BMCBI
2008
200views more  BMCBI 2008»
9 years 10 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
BMCBI
2010
277views more  BMCBI 2010»
9 years 10 months ago
PCA2GO: a new multivariate statistics based method to identify highly expressed GO-Terms
Background: Several tools have been developed to explore and search Gene Ontology (GO) databases allowing efficient GO enrichment analysis and GO tree visualization. Nevertheless,...
Marc Bruckskotten, Mario Looso, Franz Cemic, Anne ...
WOB
2007
116views Bioinformatics» more  WOB 2007»
9 years 11 months ago
Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information
Abstract. We propose a method for global validation of gene clusterings. The method selects a set of informative and non-redundant GO terms through an exploration of the Gene Ontol...
Ivan G. Costa, Marcílio Carlos Pereira de S...
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