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BMCBI
2010
176views more  BMCBI 2010»
8 years 9 months ago
Haplotype association analyses in resources of mixed structure using Monte Carlo testing
Background: Genomewide association studies have resulted in a great many genomic regions that are likely to harbor disease genes. Thorough interrogation of these specific regions ...
Ryan Abo, Jathine Wong, Alun Thomas, Nicola J. Cam...
WABI
2010
Springer
170views Bioinformatics» more  WABI 2010»
8 years 10 months ago
Haplotypes versus Genotypes on Pedigrees
Abstract. Genome sequencing will soon produce haplotype data for individuals. For pedigrees of related individuals, sequencing appears to be an attractive alternative to genotyping...
Bonnie Kirkpatrick
BMCBI
2004
112views more  BMCBI 2004»
8 years 12 months ago
A double classification tree search algorithm for index SNP selection
Background: In population-based studies, it is generally recognized that single nucleotide polymorphism (SNP) markers are not independent. Rather, they are carried by haplotypes, ...
Peisen Zhang, Huitao Sheng, Ryuhei Uehara
TCBB
2008
115views more  TCBB 2008»
8 years 12 months ago
Highly Scalable Genotype Phasing by Entropy Minimization
A Single Nucleotide Polymorphism (SNP) is a position in the genome at which two or more of the possible four nucleotides occur in a large percentage of the population. SNPs accoun...
Alexander Gusev, Ion I. Mandoiu, Bogdan Pasaniuc
JCB
2006
140views more  JCB 2006»
8 years 12 months ago
HAPLOFREQ-Estimating Haplotype Frequencies Efficiently
A commonly used tool in disease association studies is the search for discrepancies between the haplotype distribution in the case and control populations. In order to find this d...
Eran Halperin, Elad Hazan
JCB
2006
123views more  JCB 2006»
8 years 12 months ago
Reconstructing Ancestral Haplotypes with a Dictionary Model
We propose a dictionary model for haplotypes. According to the model, a haplotype is constructed by randomly concatenating haplotype segments from a given dictionary of segments. ...
Kristin L. Ayers, Chiara Sabatti, Kenneth Lange
BMCBI
2006
135views more  BMCBI 2006»
9 years 2 days ago
iHAP - integrated haplotype analysis pipeline for characterizing the haplotype structure of genes
Background: The advent of genotype data from large-scale efforts that catalog the genetic variants of different populations have given rise to new avenues for multifactorial disea...
Chun Meng Song, Boon Huat Yeo, Erwin Tantoso, Yuch...
BMCBI
2006
109views more  BMCBI 2006»
9 years 2 days ago
HaploRec: efficient and accurate large-scale reconstruction of haplotypes
Background: Haplotypes extracted from human DNA can be used for gene mapping and other analysis of genetic patterns within and across populations. A fundamental problem is, howeve...
Lauri Eronen, Floris Geerts, Hannu Toivonen
BMCBI
2006
138views more  BMCBI 2006»
9 years 2 days ago
Approximation properties of haplotype tagging
Background: Single nucleotide polymorphisms (SNPs) are locations at which the genomic sequences of population members differ. Since these differences are known to follow patterns,...
Staal A. Vinterbo, Stephan Dreiseitl, Lucila Ohno-...
BMCBI
2008
87views more  BMCBI 2008»
9 years 4 days ago
Evaluation of two methods for computational HLA haplotypes inference using a real dataset
Background: HLA haplotype analysis has been used in population genetics and in the investigation of disease-susceptibility locus, due to its high polymorphism. Several methods for...
Bruno F. Bettencourt, Margarida R. Santos, Raquel ...
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