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ISMB
2000
11 years 8 months ago
Mining for Putative Regulatory Elements in the Yeast Genome Using Gene Expression Data
We have developed a set of methods and tools for automatic discovery of putative regulatory signals in genome sequences. The analysis pipeline consists of gene expression data clu...
Jaak Vilo, Alvis Brazma, Inge Jonassen, Alan J. Ro...
ISMB
2000
11 years 8 months ago
Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling an...
J. Michael Sauder, Roland L. Dunbrack Jr.
ISMB
2000
11 years 8 months ago
Genes, Themes, and Microarrays: Using Information Retrieval for Large-Scale Gene Analysis
The immensevolumeof data resulting from DNAmicroarray experiments, accompaniedby an increase in the numberof publications discussing gene-related discoveries, presents a majordata...
Hagit Shatkay, Stephen Edwards, W. John Wilbur, Ma...
ISMB
2000
11 years 8 months ago
Linear Modeling of Genetic Networks from Experimental Data
Eugene P. van Someren, Lodewyk F. A. Wessels, Marc...
ISMB
2000
11 years 8 months ago
Pattern Recognition of Genomic Features with Microarrays: Site Typing of Mycobacterium Tuberculosis Strains
Mycobacterium tuberculosis (M. tb.) strains differ in the number and locations of a transposon-like insertion sequence known as IS6110. Accurate detection of this sequence can be ...
Soumya Raychaudhuri, Joshua M. Stuart, Xuemin Liu,...
ISMB
2000
11 years 8 months ago
A Statistical Method for Finding Transcription Factor Binding Sites
Understanding the mechanismsthat determine the regulation of geneexpression is an important and challenging problem. A fundamental subproblem is to identify DNA-bindingsites for u...
Saurabh Sinha, Martin Tompa
ISMB
2000
11 years 8 months ago
A Pragmatic Information Extraction Strategy for Gathering Data on Genetic Interactions
We present in this paper a pragmatic strategy to perform information extraction from biologic texts. Since the emergence of the information extraction field, techniques have evolv...
Denys Proux, François Rechenmann, Laurent J...
ISMB
2000
11 years 8 months ago
Combinatorial Approaches to Finding Subtle Signals in DNA Sequences
Signal nding pattern discovery in unaligned DNA sequences is a fundamental problem in both computer science and molecular biology with important applications in locating regulator...
Pavel A. Pevzner, Sing-Hoi Sze
ISMB
2000
11 years 8 months ago
An Evaluation of Ontology Exchange Languages for Bioinformatics
Ontologies are specifications of the concepts in a given field, and of the relationships among those concepts. The development of ontologies for molecular-biology information and ...
Robin McEntire, Peter D. Karp, Neil F. Abernethy, ...
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