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10 years 6 months ago
A Model for Biased Fractionation after Whole Genome Duplication
Background: Paralog reduction, the loss of duplicate genes after whole genome duplication (WGD) is a pervasive process. Whether this loss proceeds gene by gene or through deletion...
David Sankoff, Chunfang Zheng, Baoyong Wang
201views Hardware» more  TVCG 2012»
10 years 6 months ago
Exact and Approximate Area-Proportional Circular Venn and Euler Diagrams
— Scientists conducting microarray and other experiments use circular Venn and Euler diagrams to analyze and illustrate their results. As one solution to this problem, this artic...
Leland Wilkinson
10 years 6 months ago
Wilks' phenomenon and penalized likelihood-ratio test for nonparametric curve registration
The problem of curve registration appears in many different areas of applications ranging from neuroscience to road traffic modeling. In the present work, we propose a nonparamet...
Arnak S. Dalalyan, Olivier Collier
157views more  TIT 2011»
11 years 10 months ago
Universal and Composite Hypothesis Testing via Mismatched Divergence
—For the universal hypothesis testing problem, where the goal is to decide between the known null hypothesis distribution and some other unknown distribution, Hoeffding proposed ...
Jayakrishnan Unnikrishnan, Dayu Huang, Sean P. Mey...
143views more  BMCBI 2004»
12 years 3 months ago
Comparing functional annotation analyses with Catmap
Background: Ranked gene lists from microarray experiments are usually analysed by assigning significance to predefined gene categories, e.g., based on functional annotations. Tool...
Thomas Breslin, Patrik Edén, Morten Krogh
128views more  BMCBI 2008»
12 years 3 months ago
Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sa
Background: In many research areas it is necessary to find differences between treatment groups with several variables. For example, studies of microarray data seek to find a sign...
Cornelia Frömke, Ludwig A. Hothorn, Siegfried...
95views more  BMCBI 2010»
12 years 3 months ago
Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets
Background: Theme-driven cancer survival studies address whether the expression signature of genes related to a biological process can predict patient survival time. Although this...
Esteban Czwan, Benedikt Brors, David Kipling
130views more  BMCBI 2010»
12 years 3 months ago
The behaviour of random forest permutation-based variable importance measures under predictor correlation
Background: Random forests (RF) have been increasingly used in applications such as genome-wide association and microarray studies where predictor correlation is frequently observ...
Kristin K. Nicodemus, James D. Malley, Carolin Str...
12 years 5 months ago
Testing for Homogeneity with Kernel Fisher Discriminant Analysis
We propose to investigate test statistics for testing homogeneity based on kernel Fisher discriminant analysis. Asymptotic null distributions under null hypothesis are derived, an...
Zaïd Harchaoui, Francis Bach, Eric Moulines
13 years 4 months ago
Fitts' throughput and the speed-accuracy tradeoff
We describe an experiment to test the hypothesis that Fitts' throughput is independent of the speed-accuracy tradeoff. Eighteen participants used a mouse in performing a tota...
I. Scott MacKenzie, Poika Isokoski