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JBCB
2010
138views more  JBCB 2010»
9 years 6 months ago
Hierarchical Classification of Gene Ontology Terms Using the Gostruct Method
Protein function prediction is an active area of research in bioinformatics. And yet, transfer of annotation on the basis of sequence or structural similarity remains widely used ...
Artem Sokolov, Asa Ben-Hur
TCBB
2010
80views more  TCBB 2010»
9 years 10 months ago
On the Importance of Comprehensible Classification Models for Protein Function Prediction
—The literature on protein function prediction is currently dominated by works aimed at maximizing predictive accuracy, ignoring the important issues of validation and interpreta...
Alex Alves Freitas, Daniela Wieser, Rolf Apweiler
BMCBI
2007
96views more  BMCBI 2007»
9 years 11 months ago
Protein subcellular localization prediction based on compartment-specific features and structure conservation
Motivation: Protein subcellular localization is crucial for genome annotation, protein function prediction, and drug discovery. However, since determining subcellular localization...
Emily Chia-Yu Su, Hua-Sheng Chiu, Allan Lo, Jenn-K...
BMCBI
2008
228views more  BMCBI 2008»
9 years 11 months ago
Adaptive diffusion kernel learning from biological networks for protein function prediction
Background: Machine-learning tools have gained considerable attention during the last few years for analyzing biological networks for protein function prediction. Kernel methods a...
Liang Sun, Shuiwang Ji, Jieping Ye
BMCBI
2010
142views more  BMCBI 2010»
9 years 11 months ago
Classification of protein sequences by means of irredundant patterns
Background: The classification of protein sequences using string algorithms provides valuable insights for protein function prediction. Several methods, based on a variety of diff...
Matteo Comin, Davide Verzotto
LION
2009
Springer
112views Optimization» more  LION 2009»
10 years 6 months ago
A Graph-Based Semi-supervised Algorithm for Protein Function Prediction from Interaction Maps
Abstract. Protein function prediction represents a fundamental challenge in bioinformatics. The increasing availability of proteomics network data has enabled the development of se...
Valerio Freschi
RECOMB
2003
Springer
10 years 11 months ago
An integrated probabilistic model for functional prediction of proteins
We develop an integrated probabilistic model to combine protein physical interactions, genetic interactions, highly correlated gene expression network, protein complex data, and d...
Minghua Deng, Ting Chen, Fengzhu Sun
ICML
2006
IEEE
11 years 9 days ago
A graphical model for predicting protein molecular function
We present a simple statistical model of molecular function evolution to predict protein function. The model description encodes general knowledge of how molecular function evolve...
Barbara E. Engelhardt, Michael I. Jordan, Steven E...
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