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RECOMB
2004
Springer
9 years 11 months ago
Designing multiple simultaneous seeds for DNA similarity search
The challenge of similarity search in massive DNA sequence databases has inspired major changes in BLAST-style alignment tools, which accelerate search by inspecting only pairs of...
Yanni Sun, Jeremy Buhler
RECOMB
2004
Springer
9 years 11 months ago
Computational identification of evolutionarily conserved exons
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multispecies version of the ab initio gene prediction problem. These models ...
Adam C. Siepel, David Haussler
RECOMB
2004
Springer
9 years 11 months ago
A discriminative model for identifying spatial cis-regulatory modules
Transcriptional regulation is mediated by the coordinated binding of transcription factors to the upstream regions of genes. In higher eukaryotes, the binding sites of cooperating...
Eran Segal, Roded Sharan
RECOMB
2004
Springer
9 years 11 months ago
Chromosomal breakpoint re-use in the inference of genome sequence rearrangement
In order to apply gene-order rearrangement algorithms to the comparison of genome sequences, Pevzner and Tesler [9] bypass gene finding and ortholog identification, and use the or...
David Sankoff, Phil Trinh
RECOMB
2004
Springer
9 years 11 months ago
Structured motifs search
In this paper we describe an algorithm for the localization of structured models, i.e. sequences of (simple) motifs and distance constraints. It basically combines standard patter...
Alberto Policriti, Nicola Vitacolonna, Michele Mor...
RECOMB
2004
Springer
9 years 11 months ago
Comparing in situ mRNA expression patterns of drosophila embryos
In situ staining of a target mRNA at several time points during the development of a D. melanogaster embryo gives one a detailed spatio-temporal view of the expression pattern of ...
Hanchuan Peng, Eugene W. Myers
RECOMB
2004
Springer
9 years 11 months ago
Somatic evolution of cancer
We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, wh...
Martin Nowak
RECOMB
2004
Springer
9 years 11 months ago
Reconstructing reticulate evolution in species: theory and practice
We present new methods for reconstructing reticulate evolution of species due to events such as horizontal transfer or hybrid speciation; both methods are based upon extensions of...
Luay Nakhleh, Tandy Warnow, C. Randal Linder
RECOMB
2004
Springer
9 years 11 months ago
The evolutionary capacity of protein structures
In nature, one finds large collections of different protein sequences exhibiting roughly the same three-dimensional structure, and this observation underpins the study of structur...
Leonid Meyerguz, David Kempe, Jon M. Kleinberg, Ro...
RECOMB
2004
Springer
9 years 11 months ago
Finding anchors for genomic sequence comparison
Ross Lippert, Xiaoyue Zhao, Liliana Florea, Clark ...
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