Lists2Networks: Integrated analysis of gene/protein lists

Background: Systems biologists are faced with the difficultly of analyzing results from large-scale studies that profile the activity of many genes, RNAs and proteins, applied in different experiments, under different conditions, and reported in different publications. To address this challenge it is desirable to compare the results from different related studies such as mRNA expression microarrays, genome-wide ChIP-X, RNAi screens, proteomics and phosphoproteomics experiments in a coherent global framework. In addition, linking high-content multilayered experimental results with prior biological knowledge can be useful for identifying functional themes and form novel hypotheses. Results: We present Lists2Networks, a web-based system that allows users to upload lists of mammalian genes/ proteins onto a server-based program for integrated analysis. The system includes web-based tools to manipulate lists with different set operations, to expand lists using existing mammalian networks of...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Alexander Lachmann, Avi Ma'ayan
• Keywords: Biological Knowledge, BMCBI 2010, MRNA Expression Microarrays, Protein-protein Interactions