Applying dynamic Bayesian networks to perturbed gene expression data

Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics, allowing to deal with the stochastic aspects of gene expressions and noisy measurements in a natural way, Bayesian networks appear attractive in the field of inferring gene interactions structure from microarray experiments data. However, the basic formalism has some disadvantages, e.g. it is sometimes hard to distinguish between the origin and the target of an interaction. Two kinds of microarray experiments yield data particularly rich in information regarding the direction of interactions: time series and perturbation experiments. In order to correctly handle them, the basic formalism must be modified. For example, dynamic Bayesian networks (DBN) apply to time series microarray data. To our knowledge the DBN technique has not been applied in the context of perturbation experiments. Results: We extend the ...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek Wilczynski, Jerzy Tiuryn
• Keywords: Basic Formalism, Bayesian Networks, BMCBI 2006, Time Series