Web-based analysis of the mouse transcriptome using Genevestigator

Background: Gene function analysis often requires a complex and laborious sequence of laboratory and computer-based experiments. Choosing an effective experimental design generally results from hypotheses derived from prior knowledge or experimentation. Knowledge obtained from meta-analyzing compendia of expression data with annotation libraries can provide significant clues in understanding gene and network function, resulting in better hypotheses that can be tested in the laboratory. Description: Genevestigator is a microarray database and analysis system allowing context-driven queries. Simple but powerful tools allow biologists with little computational background to retrieve information about when, where and how genes are expressed. We manually curated and qualitycontrolled 3110 mouse Affymetrix arrays from public repositories. Data queries can be run against an annotation library comprising 160 anatomy categories, 12 developmental stage groups, 80 stimuli, and 182 genetic backgr...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Oliver Laule, Matthias Hirsch-Hoffmann, Tomas Hruz, Wilhelm Gruissem, Philip Zimmermann
• Keywords: BMCBI 2006, Databases, Gene Function Analysis, Little Computational Background