Logic-Based Steady-State Analysis and Revision of Metabolic Networks with Inhibition

—This paper presents a qualitative logic-based method for the steady-state analysis and revision of metabolic networks with inhibition. The approach is able to automatically revise an initial metabolic model – through the addition and removal of whole reactions or individual substrates, products and inhibitors – in order to ensure the existence of a steady-state behaviour consistent with a set of experimental observations. We show how this can be done in a nonmonotonic logic programming setting and discuss the challenges that arise when metabolic cycles or mutual inhibitions occur in the underlying network.

• Type: Conference
• Year: 2010
• Where: CISIS
• Authors: Oliver Ray, Ken E. Whelan, Ross D. King
• Keywords: CISIS 2010, Initial Metabolic Model, Metabolic, Qualitative Logic-based Method, Software Engineering