An Application of Latent Topic Document Analysis to Large-Scale Proteomics Databases

Since the advent of public data repositories for proteomics data, readily accessible results from high-throughput experiments have been accumulating steadily. Several large-scale projects in particular have contributed substantially to the amount of identifications available to the community. Despite the considerable body of information amassed, very few successful analysis have been performed and published on this data, levelling off the ultimate value of these projects far below their potential. In order to illustrate that these repositories should be considered sources of detailed knowledge instead of data graveyards, we here present a novel way of analyzing the information contained in proteomics experiments with a ’latent semantic analysis’. We apply this information retrieval approach to the peptide identification data contributed by the Plasma Proteome Project. Interestingly, this analysis is able to overcome the fundamental difficulties of analyzing such divergent and he...

• Type: Conference
• Year: 2007
• Where: GCB
• Authors: Sebastian Klie, Lennart Martens, Juan Antonio Vizcaino, Richard G. Côté, Philip Jones, Rolf Apweiler, Alexander Hinneburg, Henning Hermjakob
• Keywords: Available Proteomics Data, GCB 2007, Proteomics Data, Public Data Repositories