Sciweavers

Share
NAR
2010

AltAnalyze and DomainGraph: analyzing and visualizing exon expression data

10 years 6 months ago
AltAnalyze and DomainGraph: analyzing and visualizing exon expression data
Alternative splicing is an important mechanism for increasing protein diversity. However, its functional effects are largely unknown. Here, we present our new software workflow composed of the open-source application AltAnalyze and the Cytoscape plugin DomainGraph. Both programs provide an intuitive and comprehensive end-to-end solution for the analysis and visualization of alternative splicing data from Affymetrix Exon and Gene Arrays at the level of proteins, domains, microRNA binding sites, molecular interactions and pathways. Our software tools include easy-to-use graphical user interfaces, rigorous statistical methods (FIRMA, MiDAS and DABG filtering) and do not require prior knowledge of exon array analysis or programming. They provide new methods for automatic interpretation and visualization of the effects of alternative exon inclusion on protein domain composition and microRNA binding sites. These data can be visualized together with affected pathways and gene or protein inte...
Dorothea Emig, Nathan Salomonis, Jan Baumbach, Tho
Added 20 May 2011
Updated 20 May 2011
Type Journal
Year 2010
Where NAR
Authors Dorothea Emig, Nathan Salomonis, Jan Baumbach, Thomas Lengauer, Bruce R. Conklin, Mario Albrecht
Comments (0)
books