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BMCBI
2006

Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum

11 years 8 months ago
Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum
Background: Quantification of the metabolic network of an organism offers insights into possible ways of developing mutant strain for better productivity of an extracellular metabolite. The first step in this quantification is the enumeration of stoichiometries of all reactions occurring in a metabolic network. The structural details of the network in combination with experimentally observed accumulation rates of external metabolites can yield flux distribution at steady state. One such methodology for quantification is the use of elementary modes, which are minimal set of enzymes connecting external metabolites. Here, we have used a linear objective function subject to elementary modes as constraint to determine the fluxes in the metabolic network of Corynebacterium glutamicum. The feasible phenotypic space was evaluated at various combinations of oxygen and ammonia uptake rates. Results: Quantification of the fluxes of the elementary modes in the metabolism of C. glutamicum was form...
Kalyan Gayen, K. V. Venkatesh
Added 10 Dec 2010
Updated 10 Dec 2010
Type Journal
Year 2006
Where BMCBI
Authors Kalyan Gayen, K. V. Venkatesh
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