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BMCBI
2007

Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks

10 years 1 months ago
Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks
Background: Uncovering cellular roles of a protein is a task of tremendous importance and complexity that requires dedicated experimental work as well as often sophisticated data mining and processing tools. Protein functions, often referred to as its annotations, are believed to manifest themselves through topology of the networks of inter-proteins interactions. In particular, there is a growing body of evidence that proteins performing the same function are more likely to interact with each other than with proteins with other functions. However, since functional annotation and protein network topology are often studied separately, the direct relationship between them has not been comprehensively demonstrated. In addition to having the general biological significance, such demonstration would further validate the data extraction and processing methods used to compose protein annotation and protein-protein interactions datasets. Results: We developed a method for automatic extraction ...
Nikolai Daraselia, Anton Yuryev, Sergei Egorov, Il
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Nikolai Daraselia, Anton Yuryev, Sergei Egorov, Ilya Mazo, Iaroslav Ispolatov
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