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BMCBI
2007

Bioinformatics analysis of the early inflammatory response in a rat thermal injury model

11 years 1 months ago
Bioinformatics analysis of the early inflammatory response in a rat thermal injury model
Background: Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and immunosuppression. It has been hypothesized that gene expression patterns in the liver will change with severe burns, thus reflecting the role the liver plays in the response to burn injury. Characterizing the molecular fingerprint (i.e., expression profile) of the inflammatory response resulting from burns may help elucidate the activated mechanisms and suggest new therapeutic intervention. In this paper we propose a novel integrated framework for analyzing time-series transcriptional data, with emphasis on the burn-induced response within the context of the rat animal model. Our analysis robustly identifies critical expression motifs, indicative of the dynamic evolution of the inflammatory response and we further propose a putative...
Eric Yang, Timothy Maguire, Martin L. Yarmush, Fra
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Eric Yang, Timothy Maguire, Martin L. Yarmush, Francois Berthiaume, Ioannis P. Androulakis
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