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2004
Springer

Discovering temporal relations in molecular pathways using protein-protein interactions

9 years 9 months ago
Discovering temporal relations in molecular pathways using protein-protein interactions
The availability of large-scale protein-protein interaction data provides us with many opportunities to study molecular pathways involving proteins. In this paper we propose to mine temporal relations in molecular pathways by proteinprotein interaction data. In particular, we model the assembly pathways of protein complexes with interval graphs and determine the temporal order of joining the pathway for proteins by ordering the vertices in the interaction graph. We develop a tool called Xronos to perform such a computation. We then apply Xronos to the ribosome assembly pathway and present validation results for the obtained ordering. The results are promising and show the potential usage for Xronos in the study of molecular pathways. Categories and Subject Descriptors J.3 [Computer Applications]: Life and Medical Sciences General Terms Algorithms, Experimentation Keywords Interval graphs, probe interval graphs, vertex ordering, protein-protein interaction, molecular pathways, ribosoma...
Martin Farach-Colton, Yang Huang, John L. L. Woolf
Added 03 Dec 2009
Updated 03 Dec 2009
Type Conference
Year 2004
Where RECOMB
Authors Martin Farach-Colton, Yang Huang, John L. L. Woolford
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