Sciweavers

Share
ALMOB
2007

A spatio-temporal mining approach towards summarizing and analyzing protein folding trajectories

10 years 4 months ago
A spatio-temporal mining approach towards summarizing and analyzing protein folding trajectories
Understanding the protein folding mechanism remains a grand challenge in structural biology. In the past several years, computational theories in molecular dynamics have been employed to shed light on the folding process. Coupled with high computing power and large scale storage, researchers now can computationally simulate the protein folding process in atomistic details at femtosecond temporal resolution. Such simulation often produces a large number of folding trajectories, each consisting of a series of 3D conformations of the protein under study. As a result, effectively managing and analyzing such trajectories is becoming increasingly important. In this article, we present a spatio-temporal mining approach to analyze protein folding trajectories. It exploits the simplicity of contact maps, while also integrating 3D structural information in the analysis. It characterizes the dynamic folding process by first identifying spatio-temporal association patterns in contact maps, then s...
Hui Yang, Srinivasan Parthasarathy, Duygu Ucar
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2007
Where ALMOB
Authors Hui Yang, Srinivasan Parthasarathy, Duygu Ucar
Comments (0)
books