TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and e

Background: Identification of transcription factors (TFs) involved in a biological process is the first step towards a better understanding of the underlying regulatory mechanisms. However, due to the involvement of a large number of genes and complicated interactions in a gene regulatory network (GRN), identification of the TFs involved in a biology process remains to be very challenging. In reality, the recognition of TFs for a given a biological process can be further complicated by the fact that most eukaryotic genomes encode thousands of TFs, which are organized in gene families of various sizes and in many cases with poor sequence conservation except for small conserved domains. This poses a significant challenge for identification of the exact TFs involved or ranking the importance of a set of TFs to a process of interest. Therefore, new methods for recognizing novel TFs are desperately needed. Although a plethora of methods have been developed to infer regulatory genes using m...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Xiaoqi Cui, Tong Wang, Huann-Sheng Chen, Victor Busov, Hairong Wei
• Keywords: Biological Process, BMCBI 2010, Exact Tfs, Microarray Data