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BIRD
2008
Springer
158views Bioinformatics» more  BIRD 2008»
13 years 6 months ago
A Computational Method for Reconstructing Gapless Metabolic Networks
Abstract. We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of b...
Esa Pitkänen, Ari Rantanen, Juho Rousu, Esko ...
CMSB
2003
Springer
13 years 10 months ago
A Method for Estimating Metabolic Fluxes from Incomplete Isotopomer Information
Metabolic flux estimation—the problem of finding out the rates of reactions in metabolic pathways—is an important problem area in the study of metabolism. The most accurate t...
Juho Rousu, Ari Rantanen, Hannu Maaheimo, Esa Pitk...
ICLP
2009
Springer
14 years 5 months ago
Metabolic Network Expansion with Answer Set Programming
Abstract. We propose a qualitative approach to elaborating the biosynthetic capacities of metabolic networks. In fact, large-scale metabolic networks as well as measured datasets s...
Torsten Schaub, Sven Thiele
BMCBI
2010
133views more  BMCBI 2010»
13 years 5 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2006
92views more  BMCBI 2006»
13 years 4 months ago
Systematic assignment of thermodynamic constraints in metabolic network models
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are...
Anne Kümmel, Sven Panke, Matthias Heinemann