In this paper we introduce a new method of combined synthesis and inference of biological signal transduction networks. A main idea of our method lies in representing observed cau...
Background: Post-translational modifications (PTMs) have a key role in regulating cell functions. Consequently, identification of PTM sites has a significant impact on understandi...
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
We develop a new framework for inferring models of transcriptional regulation. The models in this approach, which we call physical models, are constructed on the basis of verifiab...
Background: The correlation between the expression levels of transcription factors and their target genes can be used to infer interactions within animal regulatory networks, but ...