Background: Unraveling the mechanisms that regulate gene expression is a major challenge in biology. An important task in this challenge is to identify regulatory elements, especi...
Background: Motif discovery aims to detect short, highly conserved patterns in a collection of unaligned DNA or protein sequences. Discriminative motif finding algorithms aim to i...
Abstract. In order to guarantee that the optimal motif is found, traditional pattern-driven approaches perform an exhaustive search over all candidate motifs of length l. We develo...
We introduce the notion of a multiprofile and use it for finding subtle motifs in DNA sequences. Multiprofiles generalize the notion of a profile and allow one to detect subtle co...
: Finding motifs and the corresponding binding sites is a critical and challenging problem in studying the process of gene expression. String and matrix representations are two pop...
Francis Y. L. Chin, Henry C. M. Leung, Man-Hung Si...