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» Alternative splicing and protein function
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BMCBI
2006
79views more  BMCBI 2006»
13 years 5 months ago
The effects of multiple features of alternatively spliced exons on the KA/KS ratio test
Background: The evolution of alternatively spliced exons (ASEs) is of primary interest because these exons are suggested to be a major source of functional diversity of proteins. ...
Feng-Chi Chen, Trees-Juen Chuang
BMCBI
2007
121views more  BMCBI 2007»
13 years 5 months ago
A procedure for identifying homologous alternative splicing events
Background: The study of the functional role of alternative splice isoforms of a gene is a very active area of research in biology. The difficulty of the experimental approach (in...
David Talavera, Adam Hospital, Modesto Orozco, Xav...
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
14 years 18 days ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber
BMCBI
2004
121views more  BMCBI 2004»
13 years 5 months ago
DEDB: a database of Drosophila melanogaster exons in splicing graph form
Background: A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing. We have...
Bernett T. K. Lee, Tin Wee Tan, Shoba Ranganathan
NAR
2000
152views more  NAR 2000»
13 years 5 months ago
ASDB: database of alternatively spliced genes
Version 2.1 of ASDB (Alternative Splicing Data Base) contains 1922 protein and 2486 DNA sequences. The protein entries from SWISS-PROT are joined into clusters corresponding to al...
I. Dralyuk, Michael Brudno, Mikhail S. Gelfand, Ma...