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RECOMB
2010
Springer
13 years 7 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
RECOMB
2005
Springer
14 years 6 months ago
The Pathalyzer: A Tool for Analysis of Signal Transduction Pathways
Abstract. The Pathalyzer is a program for analyzing large-scale signal transduction networks. Reactions and their substrates and products are represented as transitions and places ...
David L. Dill, Merrill Knapp, Pamela Gage, Carolyn...
CSB
2005
IEEE
130views Bioinformatics» more  CSB 2005»
13 years 11 months ago
iSimBioSys: An "In Silico" Discrete Event Simulation Framework for Modeling Biological Systems
The genome projects have provided comprehensive information about the basic building blocks of life. The next challenge is to understand how biological functions emerge from compl...
Samik Ghosh, Preetam Ghosh, Kalyan Basu, Sajal K. ...
KES
2007
Springer
13 years 12 months ago
A Hybrid Symbolic-Statistical Approach to Modeling Metabolic Networks
Biological systems consist of many components and interactions between them. In Systems Biology the principal problem is modeling complex biological systems and reconstructing inte...
Marenglen Biba, Stefano Ferilli, Nicola Di Mauro, ...
BMCBI
2006
109views more  BMCBI 2006»
13 years 5 months ago
Integrated analysis of gene expression by association rules discovery
Background: Microarray technology is generating huge amounts of data about the expression level of thousands of genes, or even whole genomes, across different experimental conditi...
Pedro Carmona-Saez, Monica Chagoyen, Andrés...