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BMCBI
2010
163views more  BMCBI 2010»
13 years 6 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
BMCBI
2007
141views more  BMCBI 2007»
13 years 6 months ago
Reconstruction of human protein interolog network using evolutionary conserved network
Background: The recent increase in the use of high-throughput two-hybrid analysis has generated large quantities of data on protein interactions. Specifically, the availability of...
Tao-Wei Huang, Chung-Yen Lin, Cheng-Yan Kao
CSB
2003
IEEE
176views Bioinformatics» more  CSB 2003»
13 years 11 months ago
3D Structural Homology Detection via Unassigned Residual Dipolar Couplings
Recognition of a protein’s fold provides valuable information about its function. While many sequence-based homology prediction methods exist, an important challenge remains: tw...
Christopher James Langmead, Bruce Randall Donald
CCE
2011
13 years 25 days ago
Computational energy-based redesign of robust proteins
The robustness of a system is a property that pervades all aspects of Nature. The ability of a system to adapt itself to perturbations due to internal and external agents, to agin...
Giovanni Stracquadanio, Giuseppe Nicosia
BMCBI
2004
114views more  BMCBI 2004»
13 years 6 months ago
Analysis of superfamily specific profile-profile recognition accuracy
Background: Annotation of sequences that share little similarity to sequences of known function remains a major obstacle in genome annotation. Some of the best methods of detectin...
James A. Casbon, Mansoor A. S. Saqi