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BMCBI
2004

Analysis of superfamily specific profile-profile recognition accuracy

13 years 4 months ago
Analysis of superfamily specific profile-profile recognition accuracy
Background: Annotation of sequences that share little similarity to sequences of known function remains a major obstacle in genome annotation. Some of the best methods of detecting remote relationships between protein sequences are based on matching sequence profiles. We analyse the superfamily specific performance of sequence profile-profile matching. Our benchmark consists of a set of 16 protein superfamilies that are highly diverse at the sequence level. We relate the performance to the number of sequences in the profiles, the profile diversity and the extent of structural conservation in the superfamily. Results: The performance varies greatly between superfamilies with the truncated receiver
James A. Casbon, Mansoor A. S. Saqi
Added 16 Dec 2010
Updated 16 Dec 2010
Type Journal
Year 2004
Where BMCBI
Authors James A. Casbon, Mansoor A. S. Saqi
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