8 search results - page 1 / 2 » Discovering Empirically Conserved Amino Acid Substitution Gr... |
ISMB
1996
13 years 7 months ago
1996
Thispaperintroducesa methodfor identifyingempirically conservedaminoacid substitution groups.In contrast with existing approachesthat viewaminoacid substitution as a pairwisepheno...
BMCBI
2008
13 years 5 months ago
2008
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
BMCBI
2010
13 years 5 months ago
2010
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
BMCBI
2006
13 years 5 months ago
2006
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
BMCBI
2008
13 years 5 months ago
2008
Background: A new algorithm has been developed for generating conservation profiles that reflect the evolutionary history of the subfamily associated with a query sequence. It is ...