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RECOMB
2005
Springer
14 years 5 months ago
Efficient Algorithms for Detecting Signaling Pathways in Protein Interaction Networks
Abstract. The interpretation of large-scale protein network data depends on our ability to identify significant sub-structures in the data, a computationally intensive task. Here w...
Jacob Scott, Trey Ideker, Richard M. Karp, Roded S...
ALGORITHMICA
2008
115views more  ALGORITHMICA 2008»
13 years 4 months ago
Algorithm Engineering for Color-Coding with Applications to Signaling Pathway Detection
Color-coding is a technique to design fixed-parameter algorithms for several NP-complete subgraph isomorphism problems. Somewhat surprisingly, not much work has so far been spent ...
Falk Hüffner, Sebastian Wernicke, Thomas Zich...
BMCBI
2006
147views more  BMCBI 2006»
13 years 4 months ago
QPath: a method for querying pathways in a protein-protein interaction network
Background: Sequence comparison is one of the most prominent tools in biological research, and is instrumental in studying gene function and evolution. The rapid development of hi...
Tomer Shlomi, Daniel Segal, Eytan Ruppin, Roded Sh...
RECOMB
2010
Springer
13 years 6 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
BIBM
2009
IEEE
151views Bioinformatics» more  BIBM 2009»
13 years 11 months ago
Detection of Gene Orthology Based on Protein-Protein Interaction Networks
Abstract—Ortholog detection methods present a powerful approach for finding genes that participate in similar biological processes across different organisms, extending our unde...
Fadi Towfic, M. Heather West Greenlee, Vasant Hona...