The prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysi...
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Background: We present a statistical method of analysis of biological networks based on the exponential random graph model, namely p2-model, as opposed to previous descriptive app...
Svetlana Bulashevska, Alla Bulashevska, Roland Eil...
Protein dispensability is fundamental to understanding of gene function and evolution. It is usually studied at the individual gene phenotype level. Recent advances in generating ...
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...