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BMCBI
2010
116views more  BMCBI 2010»
13 years 6 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
BMCBI
2007
216views more  BMCBI 2007»
13 years 5 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
BMCBI
2008
178views more  BMCBI 2008»
13 years 6 months ago
A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic ana
Background: Protein remote homology detection and fold recognition are central problems in bioinformatics. Currently, discriminative methods based on support vector machine (SVM) ...
Bin Liu, Xiaolong Wang, Lei Lin, Qiwen Dong, Xuan ...
ISNN
2004
Springer
13 years 11 months ago
Binary Input Encoding Strategy Based Neural Network for Globulin Protein Inter-residue Contacts Map Prediction
Abstract. Inter-residue contacts map prediction is one of the most important intermediate steps to the protein folding problem. In this paper, we focus on protein inter-residue con...
Guang-Zheng Zhang, De-Shuang Huang, Xin Huang
BIBE
2000
IEEE
13 years 9 months ago
Mining Residue Contacts in Proteins
In this paper we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleationpropagation model of p...
Mohammed Javeed Zaki, Shan Jin, Chris Bystroff