Mining Residue Contacts in Proteins

In this paper we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleationpropagation model of protein folding. We apply a hybrid approach, using a Hidden Markov Model to extract folding initiation sites, and then apply association mining to discover contact potentials. The new hybrid approach achieves accuracy results better than those reported previously.

• Type: Conference
• Year: 2000
• Where: BIBE
• Authors: Mohammed Javeed Zaki, Shan Jin, Chris Bystroff
• Keywords: Approach Achieves Accuracy, BIBE 2000, Bioinformatics, Contact Potentials, Hybrid Approach