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» From Cardiac Cells to Genetic Regulatory Networks
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BCS
2008
13 years 7 months ago
Beatbox - A Computer Simulation Environment for Computational Biology of the Heart
Despite over a century's study, the trigger mechanisms of cardiac arrhythmias are poorly understood. Even modern experimental methods do not provide sufficient temporal and s...
Ross McFarlane, Irina V. Biktasheva
BMCBI
2006
127views more  BMCBI 2006»
13 years 5 months ago
On the attenuation and amplification of molecular noise in genetic regulatory networks
Background: Noise has many important roles in cellular genetic regulatory functions at the nanomolar scale. At present, no good theory exists for identifying all possible mechanis...
Bor-Sen Chen, Yu-Chao Wang
BIOCOMP
2006
13 years 7 months ago
Dynamic Bayesian Network (DBN) with Structure Expectation Maximization (SEM) for Modeling of Gene Network from Time Series Gene
Exploring gene regulatory network is a key topic in molecular biology. In this paper, we present a new dynamic Bayesian network (DBN) framework embedded with structural expectatio...
Yu Zhang, Zhidong Deng, Hongshan Jiang, Peifa Jia
CEC
2007
IEEE
14 years 34 min ago
Evolving genetic regulatory networks for systems biology
— Recently there has been significant interest in evolving genetic regulatory networks with a user-determined behaviour. It is unclear whether or not artificial evolution of bi...
Dominique Chu
BMCBI
2007
197views more  BMCBI 2007»
13 years 5 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park