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» Genome-scale study of the importance of binding site context...
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GCB
2004
Springer
113views Biometrics» more  GCB 2004»
13 years 10 months ago
Feature Based Representation and Detection of Transcription Factor Binding Sites
: The prediction of transcription factor binding sites is an important problem, since it reveals information about the transcriptional regulation of genes. A commonly used represen...
Rainer Pudimat, Ernst Günter Schukat-Talamazz...
BMCBI
2008
259views more  BMCBI 2008»
13 years 5 months ago
DISCLOSE : DISsection of CLusters Obtained by SEries of transcriptome data using functional annotations and putative transcripti
Background: A typical step in the analysis of gene expression data is the determination of clusters of genes that exhibit similar expression patterns. Researchers are confronted w...
Evert-Jan Blom, Sacha A. F. T. van Hijum, Klaas J....
RECOMB
2004
Springer
14 years 5 months ago
A discriminative model for identifying spatial cis-regulatory modules
Transcriptional regulation is mediated by the coordinated binding of transcription factors to the upstream regions of genes. In higher eukaryotes, the binding sites of cooperating...
Eran Segal, Roded Sharan
WABI
2001
Springer
162views Bioinformatics» more  WABI 2001»
13 years 10 months ago
A Simple Hyper-Geometric Approach for Discovering Putative Transcription Factor Binding Sites
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The recent flood of genomic and postgenomic data opens the way for co...
Yoseph Barash, Gill Bejerano, Nir Friedman
BMCBI
2006
127views more  BMCBI 2006»
13 years 5 months ago
Using local gene expression similarities to discover regulatory binding site modules
Background: We present an approach designed to identify gene regulation patterns using sequence and expression data collected for Saccharomyces cerevisae. Our main goal is to rela...
Bartek Wilczynski, Torgeir R. Hvidsten, Andriy Kry...