Background: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated ...
Maris Lapinsh, Martin Eklund, Ola Spjuth, Peteris ...
The HIV reverse transcriptase and protease sequence database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immuno...
Robert W. Shafer, Duane R. Jung, Bradley J. Betts,...
Abstract— Using a neural network-fuzzy logic-genetic algorithm approach we generate an optimal predictor for biological activities of HIV-1 protease potential inhibitory compound...
Razvan Andonie, Levente Fabry-Asztalos, Sarah Abdu...
— A fuzzy neural network (FNN) and multiple linear regression (MLR) were used to predict biological activities of 26 newly designed HIV-1 protease potential inhibitory compounds....