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ISMB
1998
13 years 6 months ago
Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...
Imran Shah, Lawrence Hunter
BIOCOMP
2009
13 years 6 months ago
Improving Remote Homology Detection Using Sequence Properties and Position Specific Scoring Matrices
Current biological sequence comparison tools frequently fail to recognize matches between homologs when sequence similarity is below the twilight zone of less than 25% sequence id...
Gina Cooper, Michael L. Raymer
BMCBI
2007
102views more  BMCBI 2007»
13 years 5 months ago
Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties
Background: Homology is a key concept in both evolutionary biology and genomics. Detection of homology is crucial in fields like the functional annotation of protein sequences and...
Jos Boekhorst, Berend Snel
BMCBI
2007
144views more  BMCBI 2007»
13 years 4 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...